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  • About us 
    • Management
    • Living Innovation
    • Company presentation
  • Science 
    • Pipeline
    • xLink MAb platform
    • xLink BsAb platform
    • xLink MsAb platform
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    • LVGN3616
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  • LVGN6051

    Anti-CD137/4-1BB agonistic monoclonal antibody

  • Clinical trials

    Phase Ib/II

    An Open Label, Phase Ib/II Trial of LVGN6051 Combined With Anlotinib in the Treatment of Locally Advanced, Metastatic or Recurrent Refractory Soft Tissue Sarcoma
    NCT05301764
    VIEW TRIAL

    Phase I

    An Open Label, First in Human (FIH), Phase 1 Trial of LVGN6051 as Single Agent and in Combination With Pembrolizumab (MK-3475-A31/KEYNOTE-A31) in Advanced or Metastatic Malignancy
    NCT04130542
    VIEW TRIAL
     
    An Open Label, Phase 1 Trial of LVGN6051 as Single Agent and in Combination With Pembrolizumab in Advanced or Metastatic Malignancy
    NCT04694781
    VIEW TRIAL
     
    Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors
    NCT05075993
    VIEW TRIAL
    4-1bb, cd137, agonist, agonistic antibody, fcgriib, fc, immune therapy, LVGN6051, lyvgen

    More about LVGN6051

    CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule.
    CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells.
    The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion, survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
    Upon administration, anti-CD137 agonistic antibody LVGN6051 binds to and activates CD137 expressed on a variety of leukocyte subsets including activated T lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces cytokine production and promotes T-cell mediated anti-tumor immune responses.
    For more scientific rationale, please visit Cancer Immunotherapy and xLink MAb.
     

    Our Progress

    We are conducting Phase I trials of LVGN6051 alone or in combination with anti-PD-1 antibody in the USA, in combination with VEGFR TKI anlotinib in China,  in adult patients with advanced malignancies. Preliminary antitumor activity in late stage cancer patients was observed. Combination with pembrolizumab induced rapid antitumor responses in advanced cancer patients with immune-cold tumor or relapsed from prior immunotherapies. 

    If you as a patient or caregiver wish to participate in this study, please contact us at the following address: clinical@lyvgen.com or send us a message
    Contact us

    Lyvgen website is designed to provide general information about the subject matter presented. The information presented does not, and is not intended to, provide medical advice.

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Lyvgen Biopharma Website 礼进生物 英文官网
Lyvgen is a biotech company focused on developing novel therapies for cancer. Lyvgen’s xLinkAb™ functional platform creates agonist antibodies (Abs) with tumor-localized immunostimulatory activities by balancing multiple functions of candidate Abs.
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